Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes
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چکیده
منابع مشابه
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in approximately 50% of all cancers, p53 is still functionally active in the other 50%. Consequently, nutlin-3 and similar drugs could be candidates for neoadjuvant therapy in cancers with a functional p53. Cellular senescence is also a phenotype induce...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2016
ISSN: 0307-0565,1476-5497
DOI: 10.1038/ijo.2016.110